Disposition Index (DI) is not Improved with High-Intensity Intermittent Exercise in Adults with Hyperinsulinemia and Pre-Diabetes

Ancu, O., Naufahu, J., Barclay, R., Watt, P.W. and MacKenzie, R. 2021. Disposition Index (DI) is not Improved with High-Intensity Intermittent Exercise in Adults with Hyperinsulinemia and Pre-Diabetes. Clinical Diabetes and Research. 5 (1), pp. 55-61. https://doi.org/10.36959/647/495

TitleDisposition Index (DI) is not Improved with High-Intensity Intermittent Exercise in Adults with Hyperinsulinemia and Pre-Diabetes
TypeJournal article
AuthorsAncu, O., Naufahu, J., Barclay, R., Watt, P.W. and MacKenzie, R.
Abstract

The progression from pre-diabetes to overt type 2 diabetes is largely attributed to β-cell dysfunction and reduced insulin
responsiveness. Exercise improves β-cell function in type 2 diabetics, however in pre-diabetic populations there is no
data to support a similar response to acute high intensity exercise. Nine individuals diagnosed with prediabetes [HbA1c;
6.1 (0.2)%)] underwent a resting control, a continuous exercise and a high-intensity exercise trial. A labeled ([6,62H2] glucose) intravenous glucose tolerance test (IVGTT) was administered immediately after each trial to calculate β-cell function, 1st [acute (AIRg)] and 2nd phase insulin response to intravenous glucose and disposition index (DI). Data modelling indicated AIRg (P = 0.68) and 2nd phase insulin responsiveness (P = 0.294) were not different between trials. Additionally,insulin response in relation to insulin action (DI) was not statistically different between trials (P = 0.394). In conclusion,acute high intensity exercise does not improve DI and β-cell function in individuals with prediabetes.

KeywordsInsulin resistance, Pre-diabetes, β-cell function, Disposition index
JournalClinical Diabetes and Research
Journal citation5 (1), pp. 55-61
ISSN2642-5009
Year2021
PublisherScholars.Direct
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.36959/647/495
Publication dates
Published06 Feb 2021
Supplemental file
File Access Level
Open (open metadata and files)

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